Why does it have to be so difficult? You sit there, a bottle of pills in one hand, a tub of powder in the other, staring blankly at a seemingly endless wall of potions, tinctures, and tonics all with one purpose in mind – to support the way your body looks, and how you feel about it.
But how do you choose? Which is the best, or the worst? For that matter, how do you even decipher what's in the bottle in front of you, when the amount of every ingredient is masked behind a thousand promises and the ever-present, “proprietary blend.”
Confused about which “miracle breakthrough,” or “huge advance in science” to choose, you select the one that seems the most popular and go home. After three or four weeks, the only thing that's slimmer is your wallet, and you decide that all supplements are worthless.
But what if there was a better, more effective way? What if, instead of promising “breakthroughs,” “advances,” and “revolutions,” a company simply promised clinically-effective ingredients, at clinically-effective servings? What if, instead of shouting about “secrets of the trade,” a company admitted there really wasn't any – that the only true secret is who's willing to spend the time, effort, and money, to deliver an amazing product. What if this company – gasp! – told you exactly what was in the product? Wouldn't that be the better way?
Core Nutritionals' Core BURN Ultra powder is that better way. There are no gimmicks here, no tricks and trade secrets. Just the very best, most verified-effective ingredients at serving sizes known to exert powerful effects on the human body. With Core BURN Ultra, we have taken many of the same ultra-potent ingredients found in Core BURN, mixed in a few amazing new friends, and put the whole thing in a delicious, convenient, and rapidly-dissolving powder.
In the end, it's your choice: flashy magazine ads, or an unrivaled and extreme thermo that plain, flat-out works as promised. If we had to choose between a slim wallet or a slim waist, we'd choose the latter – because we'd choose Core BURN Ultra.
L-carnitine is a derivative of the amino acid lysine and, as certain conditions outpace the body's ability to produce it, l-carnitine is considered a conditionally essential amino acid. While endogenous biosynthesis of l-carnitine from the amino acids lysine and methionine is sufficient for essential processes – along with dietary sources of carnitine from protein-rich red meat, for example – dietary supplementation of carnitine may pose benefits supporting physiological conditions.
Unfortunately, due to excess metabolism of l-carnitine by microorganisms in the small intestine, exogenous supplementation with oral l-carnitine has proved ineffective. ALCAR, an acetylated version of l-carnitine, has considerably higher oral bioavailability, due likely to only partial hydrolytic metabolism. Once in the bloodstream, ALCAR plays a fundamental role in supporting the production of energy, can act as the catalyst for the beta-oxidation of long chain fatty acids by the mitochondria and supports the metabolism of carbohydrates.
Garcinia cambogia fruit extract (50% hydroxycitric acid):
Garcinia cambogia, more commonly known under a variety of names, including the tamarind, is a small tropical fruit endemic to Indonesia. This plant has come under increased media attention over the past few years, due largely to the purported effects of its principal constituent, hyrdoxycitric acid, or HCA.
HCA itself is a derivative of citric acid. This enzyme is an extra-mitochondrial enzyme (meaning it sits outside the mitochondria) chiefly supporting a process known as de novo lipogenesis – or the production of fatty acids from glucose.
Green coffee extract (50% chlorogenic acid):
Chlorogenic acids are phenolic compounds created during the metabolism of various isoquinic acids found in the leaves of both coffee and tea. In addition to the well-established sympathomimetic effects of coffee and tea's constituents, recent research suggests a range of other potential benefits for compounds such as chlorogenic acids.
Recent literature suggests that the consumption of both green coffee, as well as standardized extracts of CGAs, support the vasculature and support vasoreactivity, assisting with body weight reduction in both mice and humans, and modulate glucose metabolism via the glucose-6-phosphate pathway.
Caffeine (1,3,7-trimethylxanthine) and Theobromine (3,7-dimethyl-1H-purine-2,6-dione):
Caffeine is the most widely consumed, and perhaps one of the most reviewed, psychoactive compounds. Its physiological effects in a range of areas have been well-documented, including exercise performance, information processing, alertness and mood enhancement, attention, and awareness, along with its anti-lipogenic and lipolytic abilities.* Caffeine is also the most well-known in the methylxanthine compound class, the constituents of which inter-metabolize into one another in the human body and largely share similar effects.
Various clinical trials have demonstrated that xanthines – including caffeine and theobromine – support lipolytic (the breakdown of fat tissue into fatty acids) and oxidative (the actual ‘burning' of fat) actions as sympathomimetic amines. In less scientifically-complex parlance, this means caffeine is helping your body to preferentially use fat tissue as a fuel source for the oxidative provision of ATP (your body's energy currency).
Evidence for caffeine's capacity as a lipolytic is widely available. In a clinical study featuring four separate trials, for example, caffeine was found to significantly support fatty acid metabolism (as measured by serum fatty acid concentration), resting metabolic rate, and total fat oxidation – suggesting the preferential substrate selection spoken about above occurs in both normal and overweight individuals.* Other trials have demonstrated the effects of methylxanthines on total fat mass (reduction), lean body mass (increases), stamina and endurance, as well as cardiovascular capacity.*
Additionally, as selective cAMP potentiators, through the beta-adrenergic pathway, caffeine and theobromine have been hypothesized to exert a synergistic effect on lipolysis when combined with forskolin.*
Coleus forskohlii root extract (10% forskolin):
Coleus forskohlii is a small perennial endemic to various tropical regions in the world, including South America, sub-Saharan Africa, and India. While the West has recently taken interest in the plant due to the pharmacological properties of its primary bioactive, forskolin, Coleus forskholii preparations and tinctures have been used in both South American and African traditional folk medicinal systems, as well as extensively within Ayurveda.
Due to the ever-increasing interest in the plant's verifiable pharmacological and physiological effects, however, Coleus forksholii and its extracted constituents have been the subject of numerous animal and human clinical trials in the past decade. These trials have demonstrated the plant to have various effects and applications, including as a lipolytic and anti-lipogenic, and as a powerful antioxidant.*
A recent double-blind, randomized, and placebo-controlled human clinical trial featuring men found that the daily implementation of Coleus forskholii, combined with diet and exercise for twelve weeks, led to significantly better weight loss outcomes as compared to controls. Overweight men in the forskolin group experienced not only improved body composition (as measured by both body fat percentage and total fat mass), but also statistically significant increases in lean body mass.*
Coleus forskholii – and more specifically, forskolin – achieves this effect by rapidly, potently, and dose-dependently increasing an important metabolic enzyme known as adenylate cyclase.
In more basic terms, this means that forskolin quite literally frees up more fatty acids to be used as fuel for exercise – more or less the perfect scenario in a product such as Core BURN Ultra!
Bacopa monnieri (50% bacosides):
Bacopa monnieri, also known as the water hyssop commonly, or as Brahmi in Ayurvedic texts, is a small creeping herb endemic to sub-tropical India. The herb has been used in traditional Indian herbology for well over one thousand years, with its first recorded usage coming in the 6th century A.D.
More recently, BM has been the subject of numerous cognition and memory trials, as the plant may have a nootropic effect. Likely through modulation of the serotonin reuptake system, clinical trials in healthy humans have demonstrated that BM possesses a significant supportive effect on brain health.
Beyond cognition and memory support, BM has also been demonstrated to function as an adaptogen and relaxant – which in the Core BURN Ultra formula may help to smooth the effect curve of the product's stimulants, reducing jitteriness.*
Advantra-Z® Bitter Orange Extract (Citrus aurantium) (fruit) (50% synephrine):
Synephrine is a naturally-occurring alkaloid with adrenergic agonist activity, with a phenethylamine base structure. Despite its chemical similarity to these compounds, synephrine in its various isomers exerts unique effects on adrenergic receptors, in particular, and the human body, in general.*
Synephrine exists in three isomer forms: para-, meta- and ortho-synephrine. The molecular changes between the three isoforms are minute, but even this small change results in significant alterations to each isomer's physiological and pharmacokinetic profile. Two of synephrine's isomers, both p- and m-synephrine, have been shown to naturally occur in mammals (in low concentrations). As a sympathomimetic, synephrine has been the subject of numerous trials, assessing its effects on weight management, thermogenesis, metabolic rate, and caloric expenditure support.*
In addition to studies on synephrine in its various isomers, Advantra-Z®, the specific form of synephrine utilized in Core BURN Ultra, has itself and in combination with other ingredients, been the subject of various clinical trials in humans. In a randomized, double-blind, placebo-controlled trial featuring 70 obese adults, a formulation containing Advantra-Z® was found to support a reduction in fat mass and body weight, while leading to an increase in lean mass.*
Combined with not only caffeine, but the other ingredients in Core BURN, Advantra-Z® appears to be a powerful weapon in the arsenal for body composition and weight management.*
PURENERGY™ (Caffeine Pterostilbene Complex)
PURENERGY™ is a highly interesting, novel new dietary ingredient created by combining caffeine (at a 43% proportion) with pTeroPure, a 99% pure all-trans pterostilbene (at 53% proportion).
Pterostilbene is, in turn, itself a highly interesting compound, and the subject of considerable excitement and clinical research within the medical community. Found in small concentrations in blueberries and grapes, pterostilbene is a dimethylated version of the well-known compound resveratrol, and as a consequence, appears to share many of its beneficial physiological effects. Pterostilbene, in addition, has been hypothesized to exert unique effects in the human body through both genomic and enzymatic pathways, including functioning as an antioxidant, as well as playing a role in the regulation of glycolytic/gluconeogenic enzymes such as hexokinase, glucose-6-phosphatase, and fructose-1,6-bisphosphatase.
In combination as PURENERGY™, caffeine and pterostilbene have been the subject of a single, but promising, human trial. The results from this trial demonstrated:
- PURENERGY™ delivers almost 30% more caffeine into the blood than ordinary caffeine.
- The rate of caffeine absorption is significantly slower with PURENERGY™, by about 30% as compared to ordinary caffeine*
- The half-life of caffeine from PURENERGY™ is extended significantly by about 25% over that of ordinary caffeine.*
- At 4 hours, there was 45% more caffeine from PURENERGY™ compared to ordinary caffeine alone*
- At 6 hours, there was 51% more caffeine from PURENERGY™ compared to ordinary caffeine alone.*
- At 6 hours, subjects taking PURENERGY™ showed significantly less fatigue and greater concentration compared to baseline. Ordinary caffeine did not.*
- At 6 hours, subjects taking PURENERGY™ showed improved energy, alertness and focus compared to baseline. Ordinary caffeine did not.*
Coupled with a lack of adverse events seen in the trial, PURENERGY™ may represent a significant leap forward in the dietary supplement field.